Shuichi Ohkubo Selected Research

Multiple Myeloma

12/2019

Activity of TAS4464, a novel NEDD8 activating enzyme E1 inhibitor, against multiple myeloma via inactivation of nuclear factor κB pathways.

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Shuichi Ohkubo Research Topics

Disease

18	Neoplasms (Cancer) 02/2024 - 09/2005
3	Lung Neoplasms (Lung Cancer) 01/2023 - 09/2005
2	Gastrointestinal Stromal Tumors (Gastrointestinal Stromal Tumor) 12/2023 - 01/2023
2	Eye Diseases (Eye Disease) 12/2023 - 01/2019
2	Breast Neoplasms (Breast Cancer) 06/2020 - 01/2019
1	Nausea 12/2023
1	Hypoxia (Hypoxemia) 01/2023
1	Colorectal Neoplasms (Colorectal Cancer) 01/2023
1	Glioblastoma (Glioblastoma Multiforme) 10/2021
1	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2021
1	Multiple Myeloma 12/2019
1	Gastrointestinal Diseases (Functional Gastrointestinal Disorders) 01/2019
1	Weight Loss (Weight Reduction) 01/2019
1	Body Weight (Weight, Body) 01/2019
1	Toxic Optic Neuropathy 01/2015
1	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2015
1	Retinoblastoma (Glioblastoma, Retinal) 09/2005

Drug/Important Bio-Agent (IBA)

5	Proteins (Proteins, Gene)FDA Link 01/2023 - 01/2015
4	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 02/2024 - 06/2020
4	Heat-Shock Proteins (Heat-Shock Protein)IBA 12/2023 - 01/2015
3	Imatinib Mesylate (Gleevec)FDA Link 12/2023 - 12/2021
3	TAS4464IBA 01/2021 - 01/2019
3	TAS-116IBA 01/2020 - 01/2015
2	4- (2- fluoro- 4- ((((2- phenylacetyl)amino)thioxomethyl)amino)phenoxy)- 7- methoxy- N- methyl- 6- quinolinecarboxamideIBA 02/2024 - 01/2023
2	Sunitinib (Sutent)FDA Link 12/2023 - 01/2023
2	CreatinineIBA 12/2023 - 01/2019
2	Phosphotransferases (Kinase)IBA 10/2023 - 01/2023
2	Tyrosine Kinase InhibitorsIBA 12/2021 - 01/2020
2	TAS0728IBA 06/2020 - 01/2019
2	EnzymesIBA 12/2019 - 01/2019
2	UbiquitinIBA 12/2019 - 01/2019
2	Molecular Chaperones (Chaperone, Molecular)IBA 01/2019 - 01/2015
1	regorafenibIBA 12/2023
1	Tyrosine (L-Tyrosine)FDA Link 10/2023
1	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 10/2023
1	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA 10/2023
1	70-kDa Ribosomal Protein S6 Kinases (Ribosomal Protein S6 Kinases, 70 kDa)IBA 10/2023
1	Mitogen-Activated Protein KinasesIBA 10/2023
1	Protein Kinase D2IBA 01/2023
1	NucleotidesIBA 01/2023
1	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 01/2023
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2023
1	Granzymes (Granzyme)IBA 01/2023
1	Glial Fibrillary Acidic ProteinIBA 10/2021
1	CRISPR-Associated Protein 9IBA 10/2021
1	Transcription Factors (Transcription Factor)IBA 10/2021
1	Fluorouracil (Carac)FDA LinkGeneric 01/2021
1	Enzyme Inhibitors (Inhibitors, Enzyme)IBA 01/2021
1	Caspase 8 (Caspase-8)IBA 01/2021
1	Thymidylate SynthaseIBA 01/2021
1	UracilIBA 01/2021
1	Caspase 9IBA 01/2021
1	dUTP pyrophosphataseIBA 01/2021
1	TAS-114IBA 01/2021
1	Trastuzumab (Herceptin)FDA Link 06/2020
1	pertuzumabIBA 06/2020
1	AntibodiesIBA 06/2020
1	Immunoconjugates (Immunoconjugate)IBA 06/2020
1	Ado-Trastuzumab EmtansineIBA 06/2020
1	glucose-regulated proteinsIBA 01/2020
1	Proteasome Endopeptidase Complex (Proteasome)IBA 12/2019
1	Ligases (Synthetase)IBA 01/2019
1	Cullin Proteins (Cullins)IBA 01/2019
1	Glutamine (L-Glutamine)FDA Link 04/2010
1	TPY-835IBA 09/2005
1	Retinoblastoma ProteinIBA 09/2005
1	Antineoplastic Agents (Antineoplastics)IBA 09/2005

Therapy/Procedure

7	Therapeutics 02/2024 - 01/2015
2	Aftercare (After-Treatment) 12/2023 - 09/2005
2	Oral Administration 01/2019 - 01/2015
1	Drug Therapy (Chemotherapy) 01/2021